Medical QA dialogue datasets in RAG systems performance evaluation and ChatGPT optimization

This study evaluates the effectiveness of Chinese doctor-patient dialogues as retrieval sources for Retrieval-Augmented Generation (RAG) in clinical question answering. Using ChatGPT-3.5 as a baseline and extending to GPT-4o and GPT-5, we compare multiple retrieval pipelines, including dense retrieval, Cross-Encoder reranking, Reciprocal Rank Fusion (RRF), and Cascade RRF→Rerank. Experimental results show that dialogue-based retrieval significantly improves generation quality relative to direct prompting (e.g., ROUGE-1-f: +12.6%, BERTScore_F1: +1.5%, p < 0.05). Among retrieval strategies, Rerank-only provides the best accuracy-latency balance, while the cascade pipeline introduces noise and yields no additional benefit. Under identical retrieval settings, GPT-4o achieves stronger automatic metrics and 4-5× lower latency, whereas GPT-5 receives slightly higher human preference scores (+ 0.08, p < 0.001), indicating a trade-off between efficiency and perceived coherence. Expert evaluation further confirms improvements in readability, accuracy, and authenticity (all p < 0.001). These findings highlight that data representation and metadata structure have a greater impact on RAG performance than retrieval algorithm complexity, offering practical guidance for reliable medical QA deployment.

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Publication Details

Journal
Scientific Reports
Published
2025-12-24
DOI
https://doi.org/10.1038/s41598-025-28015-4
Primary Topic
Topic Modeling
Type
article
Field-Weighted Citation Impact
0.00

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article

Medical QA dialogue datasets in RAG systems performance evaluation and ChatGPT optimization

Hao Fan, Muretijiang Muhetaer, Ailimulati Yusupu, Munire Mutalipu et al.
Scientific Reports
Topic Modeling
article

Medical QA dialogue datasets in RAG systems performance evaluation and ChatGPT optimization

Hao Fan, Muretijiang Muhetaer, Ailimulati Yusupu, Munire Mutalipu, Wang Yifan
article en

Abstract

This study evaluates the effectiveness of Chinese doctor-patient dialogues as retrieval sources for Retrieval-Augmented Generation (RAG) in clinical question answering. Using ChatGPT-3.5 as a baseline and extending to GPT-4o and GPT-5, we compare multiple retrieval pipelines, including dense retrieval, Cross-Encoder reranking, Reciprocal Rank Fusion (RRF), and Cascade RRF→Rerank. Experimental results show that dialogue-based retrieval significantly improves generation quality relative to direct prompting (e.g., ROUGE-1-f: +12.6%, BERTScore_F1: +1.5%, p < 0.05). Among retrieval strategies, Rerank-only provides the best accuracy-latency balance, while the cascade pipeline introduces noise and yields no additional benefit. Under identical retrieval settings, GPT-4o achieves stronger automatic metrics and 4-5× lower latency, whereas GPT-5 receives slightly higher human preference scores (+ 0.08, p < 0.001), indicating a trade-off between efficiency and perceived coherence. Expert evaluation further confirms improvements in readability, accuracy, and authenticity (all p < 0.001). These findings highlight that data representation and metadata structure have a greater impact on RAG performance than retrieval algorithm complexity, offering practical guidance for reliable medical QA deployment.

Scientific ReportsVol. 15(1)
Wuhan University (CN), Xinjiang Institute of Engineering (CN)
National Natural Science Foundation of China
Openalex Percentile: Top 18%
Topic Modeling
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Medical QA dialogue datasets in RAG systems performance evaluation and ChatGPT optimization — Hao Fan, Muretijiang Muhetaer, et al. · Scientific Reports (2025) | TGRS Research Map | TGRS