Common genetic variants in <i>HIVEP3</i> are associated with cognitive SuperAging in the Amish
This study identified variants in HIVEP3 associated with SA. Previous studies have linked variants in HIVEP3 to increased risk of AD, as well as with hippocampal volume and cognitive trajectories in unimpaired adults, suggesting that variants in HIVEP3 may influence both AD risk and cognitive performance in unimpaired individuals. These findings indicate that HIVEP3 represents a plausible candidate for further investigation into the mechanisms promoting exceptional cognitive performance in older adults.
Authors
- Daniel A. Dorfsman
- Kristy Miskimen
- Michael Cuccaro
- Leighanne R. Main (ORCID: https://orcid.org/0000-0002-8828-8066)
- Jason E. Clouse
- Sharlene D. Herington
- Yining Liu
- Sherri D. Hochstetler
- Jeffery M. M Vance
- Michael B. Prough
- Reneé A. Laux
- Laura J. Caywood
- Yeunjoo E. Song (ORCID: https://orcid.org/0000-0002-7452-3731)
- William K. Scott (ORCID: https://orcid.org/0000-0001-9336-6404)
- Sarada L. Fuzzell
- Alan J. Lerner
- Audrey Lynn
- Alex V. Gulyayev
- Margaret Pericak‐Vance
- Ping Wang
- Noel C. Moore
- Jonathan L Haines
- Paula K. Ogrocki
- Larry D Adams
- Susan H. Slifer
Institutions
- University of Miami (US)
- University Hospitals of Cleveland (US)
- Dr. John T. Macdonald Foundation (US)
- University School (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104917
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00