Multiparametric Postmortem MRI and Histopathological Analysis Reveals Complex Signal Origins of White Matter Hyperintensity in Alzheimer's Disease

In conclusion, the joint analysis of high-resolution postmortem MRI and histopathology revealed a complex signal origin of WMHs, characterized by elevated diffusivity and prolonged T1 and T2 relaxation times, which correlate with various histological findings. This preliminary study may provide insights into the signal composition of WMHs in vivo. Figure 1. Representative half hemisphere MRI data used to evaluate WMHs. Figure 2. High-resolution MRI of small tissue cassettes at 3T and (B) Histology of WMHs using LFB, MBP, GFAP, and IBA1 staining of WMHs. Figure 3. Spider plot of the multiparametric measurements between (A) NAWM and (B) WMHs from a single subject.