Lower amyloid and small vessel disease in unimpaired older adults with Down syndrome
Older adults with DS who remain cognitively-stable had lower amyloid and posterior WMH, while those that maintain low amyloid at older ages had lower tau and microbleeds. Future work will investigate protective factors that may contribute to biomarker and clinical variability, even in the context of genetically determined AD risk.
Authors
- Dana Tudorascu (ORCID: https://orcid.org/0000-0003-4675-3692)
- Benjamin L. Handen (ORCID: https://orcid.org/0000-0001-9550-1665)
- Adam M. Brickman (ORCID: https://orcid.org/0000-0002-5125-8226)
- Anna C. Smith
- Juyoung Hahm
- Patrick J. Lao (ORCID: https://orcid.org/0000-0003-2243-3547)
- Sigan L. Hartley (ORCID: https://orcid.org/0000-0002-0186-6282)
- José Gutierrez (ORCID: https://orcid.org/0000-0002-2175-8078)
- Mohamad J. Alshikho
- Michael A. Yassa (ORCID: https://orcid.org/0000-0002-8635-1498)
- Lisi Flores Aguilar (ORCID: https://orcid.org/0000-0002-7962-7433)
- Bradley T Christian
- Donna M. Wilcock
- Elizabeth Head
- Natalie C. Edwards
- Mark Mapstone
- H. Diana Rosas
Institutions
- University of Wisconsin–Madison (US)
- Harvard University (US)
- University of Pittsburgh (US)
- University of California, Irvine (US)
- Columbia University Irving Medical Center (US)
- Massachusetts General Hospital (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- Institute on Aging (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_099396
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 0.00