Dissecting the Mechanisms of Apolipoprotein E, Blood‐Brain Barrier, and Amyloid Beta Provide insights into Alzheimer's Disease Pathogenesis

APOE4 contributes to AD pathogenesis, mainly through BBB integrity and pathways dependent on amyloid beta. Therefore, APOE4-targeted therapy could be useful for Alzheimer's disease treatment.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_101337
Primary Topic
Alzheimer's disease research and treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Dissecting the Mechanisms of Apolipoprotein E, Blood‐Brain Barrier, and Amyloid Beta Provide insights into Alzheimer's Disease Pathogenesis

Abayomi M. Ajayi, Musa Omoyine Iliyasu
Alzheimer s & Dementia
Alzheimer's disease research and treatments
article

Dissecting the Mechanisms of Apolipoprotein E, Blood‐Brain Barrier, and Amyloid Beta Provide insights into Alzheimer's Disease Pathogenesis

Abayomi M. Ajayi, Musa Omoyine Iliyasu
article en

Abstract

APOE4 contributes to AD pathogenesis, mainly through BBB integrity and pathways dependent on amyloid beta. Therefore, APOE4-targeted therapy could be useful for Alzheimer's disease treatment.

Alzheimer s & DementiaVol. 21(S1)
Kogi State University (NG)
Openalex Percentile: Top 33%
Alzheimer's disease research and treatments
DOIOpen Access PDFOpenAlex
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Dissecting the Mechanisms of Apolipoprotein E, Blood‐Brain Barrier, and Amyloid Beta Provide insights into Alzheimer's Disease Pathogenesis — Abayomi M. Ajayi, Musa Omoyine Iliyasu · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS