Data‐driven staging of postmortem neuropathology corroborates Braak staging and in‐vivo clinical and cognitive assessments in Alzheimer's’ and Parkinson's diseases

Data-driven approaches can elucidate neuropathological progression in PD and AD and capture additional nuances compared to previously used linear staging techniques. Here we first verify that as a staging tool, SuStaIn can corroborate Braak LB and tangle staging systems and provide a more quantitative model of deviations in individual cases. We further extend this approach in a large sample of postmortem AD neuropathology, showing that SuStaIn-derived patient stages applied to both tangles and plaques were associated with their clinical disease stage and cognitive performance.