MTHFR 1298C and 677T Interactions with APOE e4 and White Matter Hyperintensity Volume on Amyloid‐Positive Status in Cognitively Unimpaired Older Adults

CU individuals who carry the APOE e4 and 677T allele of MTHFR are more likely to be classified as amyloid-positive. Treatments that target vascular-related APOE e4 and MTHFR 677T pathways may help ameliorate downstream amyloid pathology in AD.

Authors

Institutions

Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_097655
Primary Topic
Folate and B Vitamins Research
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

MTHFR 1298C and 677T Interactions with APOE e4 and White Matter Hyperintensity Volume on Amyloid‐Positive Status in Cognitively Unimpaired Older Adults

Brandon X. Pitts, Vivek Devadas, Dillan Patel, Ignazio Stefano Piras et al.
Alzheimer s & Dementia
Folate and B Vitamins Research
article

MTHFR 1298C and 677T Interactions with APOE e4 and White Matter Hyperintensity Volume on Amyloid‐Positive Status in Cognitively Unimpaired Older Adults

Brandon X. Pitts, Vivek Devadas, Dillan Patel, Ignazio Stefano Piras, Y. Su, Kewei Chen, Ji Luo, Michael H. Malek‐Ahmadi
article en

Abstract

CU individuals who carry the APOE e4 and 677T allele of MTHFR are more likely to be classified as amyloid-positive. Treatments that target vascular-related APOE e4 and MTHFR 677T pathways may help ameliorate downstream amyloid pathology in AD.

Alzheimer s & DementiaVol. 21(S2)
Marquette University (US), Alzheimer's Association (US), Translational Genomics Research Institute (US), University of Arizona (US), University of Phoenix (US), Mayo Clinic in Arizona (US), Banner Alzheimer’s Institute, Arizona Alzheimer’s Consortium, Phoenix College (US), Arizona State University (US), Rice University (US)
Openalex Percentile: Top 28%
Folate and B Vitamins Research
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.