Ginger Moxibustion Activates TRPV1 to Modulate the Locus Coeruleus-Spinal Cord-Uterus Pathway and Alleviates Primary Dysmenorrhea in Rats
Ginger moxibustion at "Shenque" (CV8) and "Guanyuan" (CV4) acupoints exerts synergistic analgesic and anti-inflammatory effects by activating the TRPV1 channels in acupoint areas, initiating the bidirectional regulation of the locus coeruleus-spinal cord-uterus norepinephrine (NE) pathway, and inducing M2 polarization of macrophages.
Authors
- Liyun Yang (ORCID: https://orcid.org/0009-0000-1304-5679)
- Min Zhou (ORCID: https://orcid.org/0000-0003-1336-2097)
- Shuqi Mi
- X. Wang
- Di Wang (ORCID: https://orcid.org/0009-0001-0371-010X)
- Zhiguo Zhao (ORCID: https://orcid.org/0009-0002-9149-4511)
- Xinhua Li
- Kuo Bi
Institutions
- Hebei University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Pain Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/jpr.s554548
- Primary Topic
- Menstrual Health and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00