Global multi‐omics analysis of brain‐targeting exerkines in progressive treadmill‐exercised rodents

Contrary to previous studies, our analysis shows that brain-targeting exerkines remained unchanged in the brain after exercise, challenging the notion of a body-brain exerkine axis and questioning its role in neuroprotection and cognitive benefits.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_101454
Primary Topic
Clusterin in disease pathology
Type
article
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article

Global multi‐omics analysis of brain‐targeting exerkines in progressive treadmill‐exercised rodents

Hash Brown Taha
Alzheimer s & Dementia
Clusterin in disease pathology
article

Global multi‐omics analysis of brain‐targeting exerkines in progressive treadmill‐exercised rodents

Hash Brown Taha
article en

Abstract

Contrary to previous studies, our analysis shows that brain-targeting exerkines remained unchanged in the brain after exercise, challenging the notion of a body-brain exerkine axis and questioning its role in neuroprotection and cognitive benefits.

Alzheimer s & DementiaVol. 21(S1)
University of Southern California (US)
Openalex Percentile: Top 31%
Clusterin in disease pathology
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Global multi‐omics analysis of brain‐targeting exerkines in progressive treadmill‐exercised rodents — Hash Brown Taha · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS