Loss of MMP9 leads to altered inflammation and ECM interactions in a mouse model of cerebral small vessel disease
Our findings suggest that MMP9 plays a key role in the inflammatory response associated with HHcy-induced cSVD. The absence of MMP9 led to reduced expression of several inflammation-related genes as well as an increase in ECM interacting genes from macrophages, though differences in gene expression profiles between wild-type and MMP9<sup>-/-</sup> mice highlight distinct molecular pathways. Further studies are needed to fully understand MMP9's role in cSVD progression.
Authors
- Erica M. Weekman (ORCID: https://orcid.org/0000-0003-1252-6547)
- Donna M. Wilcock (ORCID: https://orcid.org/0000-0003-3388-1564)
- Joshua Lykins (ORCID: https://orcid.org/0009-0002-9276-0092)
- Tiffany L. Sudduth
- Sherika N. Johnson
- Katelynn E. Krick
- Colin B Rogers
Institutions
- University of Kentucky (US)
- Neurosciences Institute (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105564
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00