Association between False Positive Misclassification and Modifiable Factors in Alzheimer's Disease Prediction Models among a Diverse Community Based Cohort

Among Hispanics (n = 35/293 were FP), in the SVM model that utilized the Aβ42/40 ratio, there was a significant association between those who were classified as FP and hypothyroidism (p = 0.024) while a trend towards significance was found for Blacks (n = 139/729 were FP; p = 0.053) with no relationship found for non-Hispanic Whites (NHW). Among non-Hispanic whites (n = 82/354 were FP), in the SVM model that utilized Aβ 40, 42, the ratio and NfL, a significant association was found between those who were classified as FP and both depression (p = 0.023) and worry (p = 0.042). No association was found between the select modifiable factors and those classified as FN CONCLUSION: Differences were shown across race/ethnic group in the link between those classified as FP and modifiable factors with a medical modifier found to be associated for Blacks and Hispanics while psychiatric modifiers were found to be associated for NHWs. This highlights potential therapeutic avenues.