Tunneling nanotubes in microglia‐synapse crosstalk and inflammation
Microglia respond to AD-relevant pro-inflammatory cues with increased TNT expression, CR and oAβ localization to TNTs, and enhanced TNT-mediated interactions with synaptic elements. Thus, TNT composition and functions are environmental context dependent. Inflammation-inducible TNTs may participate in complement-dependent synaptic remodeling and/or pathological protein trafficking. CD81 represents a promising marker for in vivo investigations of the microglial TNT-synapse interface during chronic inflammation, aging, and AD.
Authors
- Euan Parnell (ORCID: https://orcid.org/0000-0002-2590-2786)
- Colleen R. Zaccard (ORCID: https://orcid.org/0000-0003-0977-2990)
- Isabel R. Gippo (ORCID: https://orcid.org/0009-0009-1729-183X)
- Marc Dos Santos (ORCID: https://orcid.org/0000-0002-6101-5631)
- Skyler Zur
- Peter Penzes
- Changiz Geula
- Blair L Eckman
Institutions
- Northwestern University (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_102358
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00