Role of prior HPV infection and CD4 T-cell count in modulating cellular immune responses to a three-dose nonavalent HPV vaccine schedule in PWH receiving ART
Our study revealed a coordinated T-cell response against HPV16 and 18 after Gardasil9® vaccine in PWH, including those with a history of HPV infection. PWH with a lower CD4 T-cell count remains a group who may not mount a fully protective immune response and, therefore, may require additional protection or ad hoc vaccination strategies. These data reinforce the key role of basal CD4 level in modulating the immune response over time, while prior HPV infection did not significantly affect the rate and quality of the response.
Authors
- Miriam Lichtner (ORCID: https://orcid.org/0000-0002-7730-3953)
- Sara Giovanna De Maria
- Cristina Giambi (ORCID: https://orcid.org/0000-0002-6011-4806)
- Alessandro Tavelli (ORCID: https://orcid.org/0000-0001-5899-451X)
- Claudio Maria Mastroianni (ORCID: https://orcid.org/0000-0002-1286-467X)
- Maria Antonella Zingaropoli (ORCID: https://orcid.org/0000-0001-9479-8559)
- Valeria Belvisi (ORCID: https://orcid.org/0000-0002-5835-1597)
- L Ansaldo (ORCID: https://orcid.org/0000-0003-1597-3393)
- Anna Carraro (ORCID: https://orcid.org/0000-0001-7399-5262)
- Eeva Tortellini (ORCID: https://orcid.org/0000-0002-3110-5193)
- Federica Dominelli (ORCID: https://orcid.org/0000-0002-8059-5088)
- Sara Teresinha Corazza (ORCID: https://orcid.org/0000-0002-2684-2412)
- Mariasilvia Guardiani (ORCID: https://orcid.org/0000-0001-5874-684X)
- C Falvino
- Cosmo Del Borgo (ORCID: https://orcid.org/0000-0002-7715-1232)
- F. Mengoni
- Raffaella Marocco
- Silvia Garattini
- Mirko Barresi
Institutions
- University of Pavia (IT)
- Ospedale Santa Maria Goretti (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1186/s12916-025-04504-1
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sapienza Università di Roma