Characterization of myelin compromise in rats with Alzheimer's‐like tauopathy

Our findings suggest that axonal damage caused by abnormal tau accumulation and phagocytosis by microglia and astrocytes can lead to myelin pathology and loss. The resulting demyelination may signal OPCs to differentiate to facilitate remyelination.

Authors

Liu Ai (ORCID: https://orcid.org/0000-0001-8222-2157)

Institutions

McGill University (CA)

Publication Details

Journal: Alzheimer s & Dementia
Published: 2025-12-01
DOI: https://doi.org/10.1002/alz70855_100442
Primary Topic: Neurogenesis and neuroplasticity mechanisms
Type: article
Field-Weighted Citation Impact: 0.00

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article

Characterization of myelin compromise in rats with Alzheimer's‐like tauopathy

Liu Ai

Dec 1, 2025

Alzheimer s & Dementia

Neurogenesis and neuroplasticity mechanisms

article

Characterization of myelin compromise in rats with Alzheimer's‐like tauopathy

Liu Ai

December 1, 2025article en

Abstract

Alzheimer s & DementiaVol. 21(S1)

McGill University (CA)

Openalex Percentile: Top 29%

Neurogenesis and neuroplasticity mechanisms

DOI Open Access PDF OpenAlex

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Characterization of myelin compromise in rats with Alzheimer's‐like tauopathy — Liu Ai · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS