Sex and apolipoprotein E (APOE) genotype Interact to impact relationships among sleep, Alzheimer's disease biomarkers, and memory in older adults
Our findings show that NREM sleep stages influence overnight memory retention in older men and women, depending on APOE genotype and CSF AD biomarkers, suggesting that sex differences in long-term memory retention are shaped by interactions between sleep and AD pathology.
Authors
- Ivy Y. Chen (ORCID: https://orcid.org/0000-0002-6739-3211)
- Negin Sattari (ORCID: https://orcid.org/0000-0002-3974-9030)
- Bryce A. Mander (ORCID: https://orcid.org/0000-0002-0831-7980)
- Kitty K. Lui (ORCID: https://orcid.org/0000-0001-7586-0118)
- Kate E. Sprecher (ORCID: https://orcid.org/0000-0002-7918-7108)
- Ruth M. Benca (ORCID: https://orcid.org/0000-0002-5895-817X)
- Gwendlyn Kollmorgen (ORCID: https://orcid.org/0000-0003-4014-9718)
- Kaj Blennow
- Brady A. Riedner (ORCID: https://orcid.org/0000-0002-8393-1737)
- Clara Quijano‐Rubio (ORCID: https://orcid.org/0000-0001-9050-3282)
- Barbara B. Bendlin
- Miranda G. Chappel‐Farley
- Henrik Zetterberg
- Abhishek Dave
Institutions
- Roche (Switzerland) (CH)
- University of Wisconsin System (US)
- University of Wisconsin–Madison (US)
- University of California, Irvine (US)
- San Diego State University (US)
- Profu (Sweden) (SE)
- Roche Pharma AG (Germany) (DE)
- Wisconsin Division of Public Health (US)
- Wake Forest University (US)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105374
- Primary Topic
- Sleep and related disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00