Distribution of big tau isoforms in the human central and peripheral nervous system
Our study provides the first protein-level evidence for expanded repertoire of tau isoforms in the human nervous system. Interestingly, brain regions overlapping with relatively lower big tau are more susceptible to neurofibrillary tangle formation, suggesting divergent roles for different tau isoforms in disease. Our findings provide new insights into the basic biology of big tau in humans, crucial for understanding its pathophysiological functions.
Authors
- Cindy V. Ly (ORCID: https://orcid.org/0000-0002-7063-5170)
- Celeste M M. Karch (ORCID: https://orcid.org/0000-0002-6854-5547)
- Timothy M. Miller (ORCID: https://orcid.org/0000-0002-3424-5511)
- Chihiro Sato (ORCID: https://orcid.org/0000-0002-7639-8727)
- Rama K. Koppisetti (ORCID: https://orcid.org/0000-0002-7539-4572)
- Justin Melendez (ORCID: https://orcid.org/0000-0003-3629-3274)
- Nupur Ghoshal (ORCID: https://orcid.org/0000-0002-6680-6731)
- Kanta Horie (ORCID: https://orcid.org/0000-0001-7736-2614)
- Soumya Mukherjee (ORCID: https://orcid.org/0000-0002-5334-7847)
- Randall J. Bateman
- Nicolas R. Barthélemy
Institutions
- Washington University in St. Louis (US)
- Orthopedic Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105528
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00