Inhibition of RACGAP1 sensitizes triple-negative breast cancer cells to ferroptosis by regulating CPT1A-dependent fatty acid metabolism
Inhibition of RACGAP1 sensitized TNBC cells to ferroptosis by inhibiting CPT1A-mediated FA metabolism. Targeting RACGAP1 might be feasible strategy for TNBC management.
Authors
- Kexin Kang (ORCID: https://orcid.org/0000-0002-7124-3240)
- Jun Ma (ORCID: https://orcid.org/0000-0002-0790-5270)
- Hongyi Wei (ORCID: https://orcid.org/0000-0003-1041-7953)
- Hua Ye (ORCID: https://orcid.org/0000-0003-1484-4151)
- Rui Zhan
- Zhike Zhou
- Wenqiang Cong
- Lu Wang
Institutions
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1186/s13046-025-03568-4
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52