Spatial molecular characterization of early Alzheimer's disease neuropathology in aged Vervet monkeys
Opportunities to systematically study early AD in humans are scarce, and late in the disease progression vulnerable brain regions are devastated by pathology. The current results demonstrate the significant potential of leveraging powerful molecular techniques in the vervet model of early AD to probe cell type specific mechanisms driving the earliest changes of AD and thus identify novel therapeutic targets.
Authors
- Suzanne Craft (ORCID: https://orcid.org/0000-0003-0591-8657)
- Caitlin S. Latimer (ORCID: https://orcid.org/0000-0003-3727-4278)
- Miranda E. Orr (ORCID: https://orcid.org/0000-0002-0418-2724)
- C SHIVELY
- Mamatha Damodarasamy (ORCID: https://orcid.org/0009-0001-6121-8420)
- Timothy C. Orr
- Angela Wilson (ORCID: https://orcid.org/0009-0000-4426-8349)
- Emily E. Killingbeck Schneidereit
- C. Dirk Keene
- Thomas C. Register
- William Harrison
Institutions
- University of Washington (US)
- Washington University in St. Louis (US)
- Wake Forest University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106882
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00