GAB2 regulates lipid metabolism by activating the MEK/ERK/c-Myc pathway: impact on renal cell carcinoma progression

GAB2 enhances lipid accumulation by activating MEK/ERK/c-Myc pathway, thereby promoting RCC progression. GAB2 is a potential target for RCC management.

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Publication Details

Journal
European journal of medical research
Published
2025-12-24
DOI
https://doi.org/10.1186/s40001-025-03654-5
Primary Topic
Cancer, Hypoxia, and Metabolism
Type
article
Field-Weighted Citation Impact
0.00
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article

GAB2 regulates lipid metabolism by activating the MEK/ERK/c-Myc pathway: impact on renal cell carcinoma progression

Nan Huang, Pu Qin, Weiqun Zhang, Ting Liu et al.
European journal of medical research
Cancer, Hypoxia, and Metabolism
article

GAB2 regulates lipid metabolism by activating the MEK/ERK/c-Myc pathway: impact on renal cell carcinoma progression

Nan Huang, Pu Qin, Weiqun Zhang, Ting Liu, Zhipeng Li, Zhiying Zhu, Xiaoying Li, Yan Sun, Xianming Fei
article en

Abstract

GAB2 enhances lipid accumulation by activating MEK/ERK/c-Myc pathway, thereby promoting RCC progression. GAB2 is a potential target for RCC management.

European journal of medical researchVol. 31(1)
Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN), Hangzhou Medical College (CN)
Good health and well-being
Openalex Percentile: Top 34%
Cancer, Hypoxia, and Metabolism
DOIOpen Access PDFOpenAlex
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