Interaction between human <i>APOE</i> polymorphisms and sex differences in hippocampal mitochondrial functions in lean and obese mice

Our findings suggest that female APOE4 KI mice exhibit reduced mitochondrial function under chow-fed conditions compared to male APOE4 KI mice, while a Western diet leads to mitochondrial maladaptation in male APOE4 KI mice. A Western diet in female mice is likely to further exacerbate the observed sex differences in mitochondrial function, resulting in a more significant decrease in respiration capacities in APOE4 females compared to APOE3 females and/or APOE4 males. Further research is needed to examine the effects of a Western diet on mitochondrial function in APOE4 female mice.