Retrotransposon LINE‐1 Activation Drives Microglial Dysregulation in Late‐Onset Alzheimer's Disease

Our findings suggest that LINE-1 activation drives microglial dysregulation, contributing to neuroinflammation and cellular dysfunction in LOAD. These data identify LINE-1 as a novel mechanism of microglial impairment and position it as a potential therapeutic target for mitigating neuroinflammatory processes in Alzheimer's disease.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_102972
Primary Topic
Neuroinflammation and Neurodegeneration Mechanisms
Type
article
Field-Weighted Citation Impact
0.00
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article

Retrotransposon LINE‐1 Activation Drives Microglial Dysregulation in Late‐Onset Alzheimer's Disease

Falak Sher
Alzheimer s & Dementia
Neuroinflammation and Neurodegeneration Mechanisms
article

Retrotransposon LINE‐1 Activation Drives Microglial Dysregulation in Late‐Onset Alzheimer's Disease

Falak Sher
article en

Abstract

Our findings suggest that LINE-1 activation drives microglial dysregulation, contributing to neuroinflammation and cellular dysfunction in LOAD. These data identify LINE-1 as a novel mechanism of microglial impairment and position it as a potential therapeutic target for mitigating neuroinflammatory processes in Alzheimer's disease.

Alzheimer s & DementiaVol. 21(S1)
Earth Island Institute (US)
Quality Education
Openalex Percentile: Top 38%
Neuroinflammation and Neurodegeneration Mechanisms
DOIOpen Access PDFOpenAlex
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Retrotransposon LINE‐1 Activation Drives Microglial Dysregulation in Late‐Onset Alzheimer's Disease — Falak Sher · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS