Plasma sphingomyelins are associated with plasma total‐Tau in presymptomatic Alzheimer's disease

Elevated plasma total-Tau levels were associated with higher plasma sphingomyelins exclusively in CN Aβ+ individuals, suggesting a link between tau release from neuronal damage and sphingomyelin-associated biochemical pathways in the presymptomatic stage of AD. Furthermore, higher levels of total-Tau-associated sphingomyelins in plasma were correlated with lower cortical-Aβ load in CN Aβ+ individuals, likely reflecting early sphingomyelin-mediated compensatory mechanisms against AD pathogenesis. These findings highlight the potential of total-Tau-associated sphingomyelins as markers for understanding the mechanisms involved in presymptomatic AD.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_101826
Primary Topic
Alzheimer's disease research and treatments
Type
article
Field-Weighted Citation Impact
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article

Plasma sphingomyelins are associated with plasma total‐Tau in presymptomatic Alzheimer's disease

James D. Doecke, Hamid R. Sohrabi, Manohar L. Garg, Kaj Blennow et al.
Alzheimer s & Dementia
Alzheimer's disease research and treatments
article

Plasma sphingomyelins are associated with plasma total‐Tau in presymptomatic Alzheimer's disease

James D. Doecke, Hamid R. Sohrabi, Manohar L. Garg, Kaj Blennow, Nicholas W. Ashton, Ralph N Martins, Tahmida Sharmin, Henrik Zetterberg, Pratishtha Chatterjee
article en

Abstract

Elevated plasma total-Tau levels were associated with higher plasma sphingomyelins exclusively in CN Aβ+ individuals, suggesting a link between tau release from neuronal damage and sphingomyelin-associated biochemical pathways in the presymptomatic stage of AD. Furthermore, higher levels of total-Tau-associated sphingomyelins in plasma were correlated with lower cortical-Aβ load in CN Aβ+ individuals, likely reflecting early sphingomyelin-mediated compensatory mechanisms against AD pathogenesis. These findings highlight the potential of total-Tau-associated sphingomyelins as markers for understanding the mechanisms involved in presymptomatic AD.

Alzheimer s & DementiaVol. 21(S2)
Edith Cowan University (AU), University of Wisconsin–Madison (US), The University of Melbourne (AU), Murdoch University (AU), King's College London (GB), Florey Institute of Neuroscience and Mental Health (AU), Sahlgrenska University Hospital (SE), UK Dementia Research Institute (GB), Australian e-Health Research Centre (AU), Wisconsin Division of Public Health (US), National Hospital for Neurology and Neurosurgery (GB), Dementia Australia (AU), University College London (GB), University of Gothenburg (SE), University of Rajshahi (BD), Macquarie University (AU)
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Plasma sphingomyelins are associated with plasma total‐Tau in presymptomatic Alzheimer's disease — James D. Doecke, Hamid R. Sohrabi, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS