AD Biomarker NPTX2 Loss of Function Drives Sleep and Circadian Rhythm Disruption
These findings demonstrate that NPTX2 loss of function instigates SCRD by disrupting sleep architecture, orexin signaling, and neuronal synchronicity. This supports the effector role of NPTX2 in sleep regulation and highlights its potential as a therapeutic target for sleep and circadian dysfunction in aging and neurodegenerative conditions.
Authors
- Alena Savonenko (ORCID: https://orcid.org/0000-0002-0694-7268)
- Ana Maria Delgado
- Chuljung Kwak (ORCID: https://orcid.org/0000-0002-1528-6828)
- Paul Worley (ORCID: https://orcid.org/0009-0007-3214-7604)
- Meifang Xiao
- Kathryn Chung Tze Cheong
- Seung‐Eon Roh
- Arnold Bakker
- Douglas R. Galasko
- Hyung‐Bae Kwon
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- University of California San Diego (US)
- Institute for Basic Science (KR)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Korea Basic Science Institute (KR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_103059
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00