Targeting NADPH oxidase 2 suppresses the growth of esophageal squamous cell carcinoma by regulating BTG2 pathway
The carcinogenic role of NOX2 in ESCC may be associated with the regulation of BTG2 expression. The aberrant expressions of NOX2 and BTG2 are associated with the prognosis of patients with ESCC, suggesting that NOX2 and BTG2 could serve as potential biomarkers and therapeutic targets.
Authors
- Yunlei Zhang (ORCID: https://orcid.org/0000-0003-3536-9142)
- Junxing Huang (ORCID: https://orcid.org/0009-0000-7728-4126)
- Xiao-Jie Liu
- Can-Lin Yang
Institutions
- Jiangsu University (CN)
- Dalian Medical University (CN)
- Nantong University (CN)
- The Affiliated Taizhou People's Hospital of Nanjing Medical University (CN)
- Yixing People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1007/s12672-025-04345-7
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00