Identification and experimental validation of biomarkers for acute myeloid leukemia based on single-cell RNA sequencing data
This study identified AIF1, CST7, and ITGB2 as biomarkers for AML through scRNA-seq, MR, and transcription factor enrichment analysis. Additionally, in vitro experiments, including cell transfection, cell proliferation, and flow cytometry, validated the important role of these biomarkers in promoting the malignant phenotype of AML.
Authors
- Yujing Cheng
- Chan Zhang (ORCID: https://orcid.org/0000-0002-3250-9202)
- Xin Yang
- Yuanju Chen
- Qi Li
- Ying Wang
- Siyue Zhou
Institutions
- First People's Hospital of Yunnan Province (CN)
- Second People's Hospital of Yunnan Province (CN)
Publication Details
- Journal
- Molecular and Cellular Probes
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1016/j.mcp.2025.102059
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00