Stage‐dependent associations between CSF aquaporin‐4 levels and Alzheimer's Disease abnormalities

The findings highlight AQP4 association with hippocampal volume and brain metabolism. A potential biological interpretation is that AQP4 may serve a protective function in maintaining cerebral water homeostasis, offering valuable insights into cognitive decline and potential biomarkers for AD. By facilitating these processes, AQP4 might contribute to better cognitive outcomes. However, further research is required to confirm these putative mechanisms.