Exploring Alzheimer's Disease Subtype Replicability
The results demonstrate the risk of relying on unsupervised clustering for interpreting AD subtypes and recommend a framework for defining the subtypes, training clustering, and evaluating performance based on hypothesis-driven definitions grounded in the original postmortem findings.
Authors
- Alexei Taylor (ORCID: https://orcid.org/0000-0003-4190-4658)
- Hansoo Chang (ORCID: https://orcid.org/0000-0002-6882-3455)
- Michelle D Shardell (ORCID: https://orcid.org/0000-0002-5283-2082)
- Alexandra Sahl
- Ana Ferariu (ORCID: https://orcid.org/0009-0007-0035-6209)
- Wenxin Jiang (ORCID: https://orcid.org/0009-0000-1927-6531)
- Lei Wang
- Fengqing (Zoe) Zhang
- Corey T. McMillan
Institutions
- Northwestern University (US)
- University of Maryland, Baltimore (US)
- The Ohio State University (US)
- Drexel University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_103465
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00