COMPARATIVE STUDY OF THE WOUND HEALING POTENTIAL OF INSULINUM 30, PHOSPHORIC ACID 30, AND SYZYGIUM JAMBOLANUM 30 IN A DIABETIC RAT MODEL

Diabetes mellitus leads to delayed wound repair as a result of sustained hyperglycemia, microvascular impairment, neuropathy, increased oxidative stress, and dysregulated inflammatory processes. Chronic non-healing wounds, particularly diabetic foot ulcers, are a major cause of morbidity and substantially increase the risk of infection and limb amputation.The present study aimed to assess and compare the wound healing efficacy of Insulinum 30, Phosphoric acid 30, and Syzygium jambolanum 30 in streptozotocin-induced diabetic albino rats. Diabetes was experimentally induced in male albino rats using streptozotocin. An excision wound model was adopted, and the animals were randomly allocated into four groups: control (glibenclamide-treated), Insulinum 30, Phosphoric acid 30, and Syzygium jambolanum 30. Evaluation parameters included wound area measurement, percentage of wound contraction, duration of epithelization, hydroxyproline and protein content, tensile strength, blood glucose levels, and histopathological examination of wound tissue. All three homoeopathic remedies exhibited significant wound healing effects when compared with the control group. Among them, Syzygium jambolanum 30 produced the most rapid wound contraction, a reduced epithelization period, and favorable biochemical outcomes.The study offers experimental evidence that Syzygium jambolanum 30 has the most pronounced wound healing potential under diabetic conditions, followed by Insulinum 30 and Phosphoric acid 30. These results substantiate the traditional application of these remedies in the management of diabetic wounds and highlight the need for further clinical evaluation.