PolyGR‐Containing Aggregates in Alzheimer's Disease: A Novel Proteinopathy Associated with Clinical Features of AD Patients
Our findings highlight the role of vascular and metabolic risk factors, including TBI, hypertension, and hypercholesterolemia, in promoting polyGR accumulation in AD. Notably, polyGR accumulation appears to occur independently of pTau aggregation. These insights provide a deeper understanding of AD pathogenesis and suggest potential avenues for further investigation into the molecular mechanisms linking vascular and metabolic factors to polyGR pathology.
Authors
- Lien Nguyen (ORCID: https://orcid.org/0000-0001-5237-2576)
- J. C. Troncoso
- Cemal Akmese
- Stefanie Ng
- Alexandra Melloni (ORCID: https://orcid.org/0000-0002-0657-5919)
- Ana María Piddo Mijares
- Logan Bell (ORCID: https://orcid.org/0009-0005-9403-888X)
- Huong T. Phuong
- Svitlana Yegorova
- Jennifer L. Phillips
- Rodrigo Francisco Tomas
- Olga Pletnikova
- Stefan Prokop
- Bradley T. Hyman
- Laura P. W. Ranum
- H. Brent Clark
- Shu Guo
Institutions
- University of Minnesota (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- University of Florida Health (US)
- University of Florida (US)
- Florida College (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105969
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00