Dissecting Alzheimer Disease Heritability Across Multiple Populations
While family-based estimates complement previous twin-based and genome-wide studies, the wide range of narrow sense heritability estimated across populations reflects substantial variability in population-specific and unmeasured extrinsic factors, such as lifestyle and behaviors, environmental exposures, and social determinants of health. Work supported by AG074865 and AG072547 is ongoing to estimate SNP-based heritability in overlapping participants for direct comparisons with family-based heritability.
Authors
- Giuseppe Tosto (ORCID: https://orcid.org/0000-0001-7075-8245)
- Scott M. Williams (ORCID: https://orcid.org/0000-0002-4835-9544)
- Dana C. Crawford (ORCID: https://orcid.org/0000-0002-6437-6248)
- Christiane Reitz (ORCID: https://orcid.org/0000-0001-8757-7889)
- Jeffery M. M Vance
- William S. Bush (ORCID: https://orcid.org/0000-0002-9729-6519)
- Goldie S Byrd
- Margaret Pericak‐Vance
- Jonathan L Haines
- Brian W Kunkle
- Shiying Liu
Institutions
- University of Miami (US)
- Dr. John T. Macdonald Foundation (US)
- University School (US)
- Wake Forest University (US)
- Case Western Reserve University (US)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_102132
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00