Sepsis‐Induced Delirium Progresses Tau Pathology in P301S Mouse Model of Alzheimer's Disease

The preliminary findings suggest that sepsis-induced delirium may contribute to the progression of tau pathology in P301S mice. While cognitive deficits were not apparent in initial behavioral tests, the observed increase in phosphorylated tau and microglial activation in P301S CS mice indicates a potential long-term impact of sepsis on AD-like pathology. Further data collection and analysis are necessary to fully elucidate the relationship between sepsis-induced delirium and tau pathology progression in this model.