Heterozygosity of lysosomal enzyme genes and Alzheimer's disease
These data strongly implicate heterozygosity of at least five, likely more, lysosomal enzyme genes in the development of AD and these genes might be effective therapeutic targets in certain genetically-defined forms of AD.
Authors
- Thomas M. Wishart (ORCID: https://orcid.org/0000-0002-1973-6654)
- Carla M. Yuede (ORCID: https://orcid.org/0000-0001-6362-4767)
- Mia T. Bevan
- Cyril P. Pottier (ORCID: https://orcid.org/0000-0002-3049-9346)
- Clare E. Wallace (ORCID: https://orcid.org/0000-0002-6771-1435)
- Ryan T. Harrigan
- Woodrow D. Gardiner
- Dominic Kurian (ORCID: https://orcid.org/0000-0002-5924-665X)
- Mark S. Sands (ORCID: https://orcid.org/0000-0002-5559-0832)
- Maulikkumar Patel (ORCID: https://orcid.org/0000-0003-3914-2797)
- Bruno A. Benítez (ORCID: https://orcid.org/0000-0002-2699-3878)
- Niko-Petteri Nykänen (ORCID: https://orcid.org/0000-0002-3489-1441)
- Neal Goodwin (ORCID: https://orcid.org/0000-0002-1117-1740)
- Hannah M. Edwards (ORCID: https://orcid.org/0000-0001-8706-0732)
- Samantha Eaton
- John R. Cirrito (ORCID: https://orcid.org/0000-0002-7196-8786)
- Brookelyn M. Doherty
- Colin Smith
- Matthew Johnson
- Arda Cetin
Institutions
- Beth Israel Deaconess Medical Center (US)
- Roslin Institute (GB)
- Washington University in St. Louis (US)
- BD Biosciences (United States) (US)
- Washington School of Psychiatry (US)
- University of Edinburgh (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_101638
- Primary Topic
- Lysosomal Storage Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00