The Myeloid Differentiation Factor‐2 Inhibitor Alleviates Brain Mitochondrial Oxidative Stress Without Improving Cognitive Impairment in Aged‐Female Rats
MD2-inhibitor (L6H2) reduced brain mitochondrial ROS production and improved mitochondrial membrane potential change in aged-female rats, but did not improve cognitive function or overall mitochondrial health. Additionally, MDV1 had no effect on mitochondrial function or cognitive outcomes. These results suggest that MD2-inhibitor may play a role in reducing brain mitochondrial oxidative stress, the doses and treatment duration used in this study were insufficient to significantly improve cognitive function in aged-female rats.
Authors
- Busarin Arunsak (ORCID: https://orcid.org/0000-0002-5120-288X)
- Patcharapong Pantiya (ORCID: https://orcid.org/0000-0002-2181-7197)
- Nipon Chattipakorn
- Guang Liang (ORCID: https://orcid.org/0009-0005-1603-3223)
- Chanisa Thonusin
- Titikorn Chunchai
- Hiranya Pintana
- Siriporn C Chattipakorn
- Suriphan Donchada
Institutions
- Wenzhou Medical University (CN)
- Chiang Mai University (TH)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_102430
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00