X‐linked gene expression is associated with plasma <i>p</i> ‐tau217 levels via Aβ‐PET and sex in cognitively unimpaired older adults
Significant whole-blood X-linked gene expression associations with p-tau<sub>217</sub> levels in clinically normal older adults are largely moderated by Aβ-PET burden and sex. This study identified both protective and risk genes, highlighting novel gene candidates for further validation and supporting the need to study sex chromosomes in AD.
Authors
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Robert A. Rissman (ORCID: https://orcid.org/0000-0001-9245-8278)
- Logan C. Dumitrescu (ORCID: https://orcid.org/0000-0002-9782-9944)
- Michael Donohue (ORCID: https://orcid.org/0000-0001-6026-2238)
- Rachel F. Buckley (ORCID: https://orcid.org/0000-0002-5356-5537)
- Michelle Clifton
- Bernard Hanseeuw (ORCID: https://orcid.org/0000-0002-3102-6778)
- Gillian Coughlan (ORCID: https://orcid.org/0000-0003-1806-702X)
- Colin Birkenbihl (ORCID: https://orcid.org/0000-0002-7212-7700)
- Jane A. Brown (ORCID: https://orcid.org/0000-0002-2545-3693)
- Jasmeer P. Chhatwal (ORCID: https://orcid.org/0000-0002-7792-1698)
- Hannah M Klinger
- Madison Cuppels
- REMA RAMAN (ORCID: https://orcid.org/0000-0002-4096-6390)
- R. Sperling
- Hyun‐Sik Yang
- Paul S. Aisen
- Vaibhav A Janve
- Ting‐Chen Wang
- Keith A. Johnson
- Michael J. Properzi
- Mabel Seto
- Diana L Townsend
Institutions
- University of Southern California (US)
- Brigham and Women's Hospital (US)
- Autism Research Institute (US)
- Harvard University (US)
- Vanderbilt University (US)
- Massachusetts General Hospital (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_101138
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00