Impact of sex, age and glymphatic clearance on meningeal tau PET signal
Our findings demonstrate that meningeal signal of [<sup>18</sup>F]MK6240 is significantly associated with glymphatic clearance in females, while in males, it is associated with age. In contrast, [<sup>18</sup>F]FTP signal is primarily influenced by age in both sexes. These results highlight the distinct relationship between [<sup>18</sup>F]MK6240 signal and glymphatic function in females, while age appears to play a significant role in both males and females for other tracer signal patterns.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- Nesrine Rahmouni
- Belén Pascual (ORCID: https://orcid.org/0000-0002-4467-7406)
- William E. Klunk (ORCID: https://orcid.org/0000-0001-5512-0251)
- Suzanne L. Baker (ORCID: https://orcid.org/0000-0003-0209-3127)
- Firoza Zubeida Lussier (ORCID: https://orcid.org/0000-0002-6877-4825)
- Han Feng (ORCID: https://orcid.org/0000-0003-3163-8931)
- David Soleimani‐Meigooni
- Ji Yeon Lee (ORCID: https://orcid.org/0000-0002-3622-7392)
- Hsin‐Yeh Tsai
- Cécile Tissot (ORCID: https://orcid.org/0000-0002-5022-2213)
- Jenna Stevenson (ORCID: https://orcid.org/0000-0003-2848-1451)
- Hwamee Oh (ORCID: https://orcid.org/0000-0003-1156-5704)
- William J. Jagust
- Joseph Therriault
- Brian A. Gordon
- Stijn Servaes
- Pedro Rosa‐Neto
Institutions
- Houston Methodist (US)
- Lawrence Berkeley National Laboratory (US)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- Washington University in St. Louis (US)
- Brown University (US)
- Mayo Clinic in Arizona (US)
- McGill University (CA)
- University of California, Berkeley (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_099912
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00