Comparative Analysis of RNA Seq and PCR Array Data Implicates BDNF as a Potential Therapeutic Target for Alzheimer's Disease

The difference in the amount of data and statistical significance provided by the RNA bulk sequencing and the PCR array analyses provides evidence that the focused number of genes in the PCR array analysis results in greater statistical significance while sacrificing breadth. Through manipulating the expression of regulators, molecules, and diseases for the two datasets, we identified activating brain derived neurotrophic factor (BDNF) as the most effective therapeutic approach for inhibiting Alzheimer's disease. BDNF will be added to a mathematical model for AD that we are constructing to evaluate and optimize the therapeutic potential of activating BDNF to significantly inhibit AD in AD or AD+ patients.