Prediction of progression to dementia in individuals with subjective cognitive decline
Our findings suggest that an algorithm including plasma p-tau217, APOE4 genotype, executive and memory tests and 'AD-signature' cortical thickness, could refine SCD individuals' prognosis in clinical practice and optimize participant selection in preclinical AD trials.
Authors
- Rik Ossenkoppele (ORCID: https://orcid.org/0000-0003-1584-7477)
- Erik Stomrud (ORCID: https://orcid.org/0000-0002-0841-5580)
- Pontus Tideman (ORCID: https://orcid.org/0000-0002-9620-7115)
- Sophie E Mastenbroek (ORCID: https://orcid.org/0009-0006-2759-9588)
- Oskar H. Hansson
- M. Sanchez
- Niklas Mattsson‐Carlgren
- Sebastian Palmqvist
- Shorena Janelidze
Institutions
- Universidad de Cantabria (ES)
- Lund University (SE)
- Marqués de Valdecilla University Hospital (ES)
- Amsterdam Neuroscience (NL)
- Skåne University Hospital (SE)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_102807
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00