Proteome-scale autoantibody profiling in PSC: Associations with clinical phenotypes and evidence for neuroendocrine deregulations
From a proteome-scale profiling of the SUPRIM cohort, we provide a short list of autoantibodies associated with clinical phenotypes and progression, along with the peptide sequences used to capture them. We identify across multiple datasets neuroendocrine deregulations in primary sclerosing cholangitis and provide a short list of related key plasma proteins. These data and technical details should facilitate validation studies, investigations of related pathophysiological mechanisms and development of low-cost tools for diagnostic or prognostic purposes.
Authors
- Aristeidis Grigoriadis (ORCID: https://orcid.org/0000-0002-3760-3513)
- Christina Villard (ORCID: https://orcid.org/0000-0003-4696-0931)
- Fredrik Edfors (ORCID: https://orcid.org/0000-0002-0017-7987)
- Dan Sun (ORCID: https://orcid.org/0000-0001-6464-5973)
- Erik von Seth (ORCID: https://orcid.org/0000-0002-6976-248X)
- Peter Nilsson (ORCID: https://orcid.org/0000-0002-4657-8532)
- Per Stål (ORCID: https://orcid.org/0000-0002-9340-5298)
- María Bueno Álvez (ORCID: https://orcid.org/0000-0002-2669-7796)
- Aiva Lundberg Båve (ORCID: https://orcid.org/0000-0002-5386-4385)
- Sofia Bergström (ORCID: https://orcid.org/0000-0003-2910-4754)
- Mathias Uhlen
- Niklas Björkström
- Ghada Nouairia
- Hannes Jansson
- Martin Cornillet
Institutions
- Karolinska University Hospital (SE)
- Örebro University (SE)
- Science for Life Laboratory (SE)
- Karolinska Institutet (SE)
- KTH Royal Institute of Technology (SE)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101719
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancerfonden
- Vetenskapsrådet
- Science for Life Laboratory
- Center for Innovative Medicine