Novel Mouse Model of TDP43‐opathy Demonstrates Paradoxical Effects of Aging on Neurodegenerative Phenotypes

We developed a novel ALS-like mouse model that allows for tight temporal and dosage control of resultant pathology. This tool can enhance efficiency in experiments studying complex genetics or aging in TDP43-opathies. Surprisingly, when young and old mice were challenged with acute hTDP43 overexpression, aging played a protective role in the subsequent ALS-like phenotype. Subsequent work will explore the mechanisms behind this age-related resilience.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_105723
Primary Topic
Amyotrophic Lateral Sclerosis Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Novel Mouse Model of TDP43‐opathy Demonstrates Paradoxical Effects of Aging on Neurodegenerative Phenotypes

Caitlyn Schaffer, Christian Battaglia, Martin Darvas, Daniel Fisher et al.
Alzheimer s & Dementia
Amyotrophic Lateral Sclerosis Research
article

Novel Mouse Model of TDP43‐opathy Demonstrates Paradoxical Effects of Aging on Neurodegenerative Phenotypes

Caitlyn Schaffer, Christian Battaglia, Martin Darvas, Daniel Fisher, Nzinga Hendricks, Alec ST Smith, NhiVan Tran
article en

Abstract

We developed a novel ALS-like mouse model that allows for tight temporal and dosage control of resultant pathology. This tool can enhance efficiency in experiments studying complex genetics or aging in TDP43-opathies. Surprisingly, when young and old mice were challenged with acute hTDP43 overexpression, aging played a protective role in the subsequent ALS-like phenotype. Subsequent work will explore the mechanisms behind this age-related resilience.

Alzheimer s & DementiaVol. 21(S1)
University of Washington (US)
Openalex Percentile: Top 31%
Amyotrophic Lateral Sclerosis Research
DOIOpen Access PDFOpenAlex
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Novel Mouse Model of TDP43‐opathy Demonstrates Paradoxical Effects of Aging on Neurodegenerative Phenotypes — Caitlyn Schaffer, Christian Battaglia, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS