Connector Hubs Accelerate the Spread of Tau Pathology in Alzheimer's Disease
Brain network topology shapes spatiotemporal tau accumulation rates and cognitive trajectories in AD. Specifically, stronger communication of tau epicenters with connector hubs that are characterized by widespread cross-network connections amplifies amyloid-related tau accumulation. This suggests that brain network architecture has a profound modulating impact on tau aggregation and disease progression in AD.
Authors
- Amir Dehsarvi (ORCID: https://orcid.org/0000-0001-7116-9741)
- Anna Steward (ORCID: https://orcid.org/0000-0002-8438-3760)
- Johannes Gnörich (ORCID: https://orcid.org/0000-0003-1554-7765)
- Fabian Hirsch (ORCID: https://orcid.org/0000-0002-5370-4031)
- Michael Schöll (ORCID: https://orcid.org/0000-0001-7800-1781)
- Nicolai Franzmeier (ORCID: https://orcid.org/0000-0001-9736-2283)
- Davina Biel (ORCID: https://orcid.org/0000-0002-2597-1992)
- Sebastian N. Roemer‐Cassiano
- Zeyu Zhu
- Anna Dewenter
- Lukas Frontzkowski
- Madleen Klonowksi
- Günter U Höglinger
- Matthias Brendel
Institutions
- German Center for Neurodegenerative Diseases (DE)
- LMU Klinikum (DE)
- Munich Cluster for Systems Neurology (DE)
- München Klinik (DE)
- Wallenberg Wood Science Center (SE)
- UK Dementia Research Institute (GB)
- Max Planck Institute for Human Cognitive and Brain Sciences (DE)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- Ludwig-Maximilians-Universität München (DE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_098847
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00