Predictive factors of axillary pathological complete response in HER2-positive breast cancer patients treated with neoadjuvant chemotherapy
QuestionIdentifying predictive factors for axillary pCR in HER2+ breast cancer patients undergoing NAC. FindingsAxillary radiological complete response predicted axillary pCR in univariate (p = 0.021) and multivariate analyses (p = 0.025), while Ki-67 was marginally significant in the multivariate model (p = 0.045). Clinical relevanceRecognizing reliable predictors of axillary pCR may support the omission of ALND in selected HER2+ patients, minimizing surgical morbidity.
Authors
- José Luis Raya-Povedano (ORCID: https://orcid.org/0000-0003-1034-4184)
- Marina Álvarez Benito (ORCID: https://orcid.org/0000-0002-0273-3393)
- Sara Romero-Martín (ORCID: https://orcid.org/0000-0003-3459-9050)
- Beatriz Rodríguez-Alonso
- Marta Rodríguez de Trujillo Campo-Cossío
- Pilar Font-Ugalde
Institutions
- Instituto Maimónides de Investigación Biomédica de Córdoba (ES)
- Hospital Universitario Reina Sofía (ES)
- University of Córdoba (ES)
- Cordoba University (US)
Publication Details
- Journal
- European Radiology
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1007/s00330-025-12241-5
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00