CSF biomarkers of neuroinflammation are associated with regional atrophy
Latent factors captured shared biological variance across related biomarkers and provided a more robust representation of underlying biological domains than single biomarkers. This approach identified synaptic dysfunction and astroglial activation as key links between AD pathology and hippocampal neurodegeneration. These findings highlight synaptic and glial pathways as promising targets for disease-modifying interventions.
Authors
- Anja Schneider (ORCID: https://orcid.org/0000-0002-3377-5828)
- Ayda Rostamzadeh (ORCID: https://orcid.org/0000-0001-5189-134X)
- Robert Perneczky (ORCID: https://orcid.org/0000-0003-1981-7435)
- Annika Spottke (ORCID: https://orcid.org/0000-0001-9854-2972)
- Serap Özlü
- Matthis Synofzik (ORCID: https://orcid.org/0000-0002-2280-7273)
- Alice Grazia (ORCID: https://orcid.org/0000-0001-8861-3183)
- Christoph Laske (ORCID: https://orcid.org/0009-0009-3434-936X)
- David Mengel (ORCID: https://orcid.org/0000-0002-4133-7182)
- Katharina Büerger (ORCID: https://orcid.org/0000-0002-5898-9953)
- Klaus Fließbach (ORCID: https://orcid.org/0000-0002-0183-7510)
- Daniel Janowitz (ORCID: https://orcid.org/0009-0003-4090-547X)
- Ingo Kilimann (ORCID: https://orcid.org/0000-0002-3269-4452)
- Julian Hellmann‐Regen (ORCID: https://orcid.org/0000-0003-0411-9204)
- Wenzel Glanz (ORCID: https://orcid.org/0000-0002-5865-4176)
- Stefan Hetzer
- Sebastian Sodenkamp (ORCID: https://orcid.org/0009-0004-9118-0621)
- Peter Dechent (ORCID: https://orcid.org/0009-0006-4005-3352)
- Josef Priller
- Eike Jakob Spruth (ORCID: https://orcid.org/0000-0002-8976-7309)
- Marie Theres Kronmüller
- Frederic Brosseron
- Boris-Stephan Rauchmann
- Jens Wiltfang
- Falk Lüsebrink
- O. Peters
- Martin Dyrba
- Michael T. Heneka
- Michael Ewers
- Frank Jessen
- Niels Hansen
- Stefan Teipel
- Emrah Düzel
- Alfredo Ramirez
Institutions
- University of Bonn (DE)
- University of Cologne (DE)
- University of Luxembourg (LU)
- University Hospital Bonn (DE)
- German Center for Neurodegenerative Diseases (DE)
- LMU Klinikum (DE)
- Institute for Neurodegenerative Disorders (US)
- Munich Cluster for Systems Neurology (DE)
- European Neuroscience Institute Göttingen (DE)
- UK Dementia Research Institute (GB)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- Hertie Institute for Clinical Brain Research (DE)
- University Hospital Cologne (DE)
- University of Rostock (DE)
- Imperial College London (GB)
- University of Aveiro (PT)
- Technical University of Munich (DE)
- University of Göttingen (DE)
- Charité - Universitätsmedizin Berlin (DE)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
- University of Sheffield (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1007/s00415-025-13564-5
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00