Humanized Klotho variants cause widespread transcriptional changes in B6 mice
These data suggest that the introduction of KL human variants to mice provides a translatable mechanistic model that will improve our understanding of the role of KL in aging and Alzheimer's Disease.
Authors
- Kevin P. Kotredes (ORCID: https://orcid.org/0000-0001-7874-4139)
- Dylan Garceau
- Christoph Preuß (ORCID: https://orcid.org/0000-0003-1039-6080)
- Anna L. Tyler (ORCID: https://orcid.org/0000-0001-8371-2377)
- Michael Sasner (ORCID: https://orcid.org/0000-0002-6612-6111)
- Gregory W Carter
Institutions
- Jackson Laboratory (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_102892
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00