Integrated Transcriptome‐Wide and miRNA Sequencing Analysis of Systemic Infection in Alzheimer's Disease Brain

These findings highlight the impact of systemic infections on neuroinflammatory responses in AD, mediated through immune-related pathways and implicating BBB dysfunction. The enrichment of vesicle transport processes suggests infections may affect the AD brain via altered cellular trafficking. Future work will integrate RNA and miRNA sequencing data to elucidate whether miRNA dysregulation contributes to the observed differential expression of target genes.