White matter hyperintensities and Alzheimer's disease pathology in heterogeneous cohorts
Total WMH volume is related to demographic characteristics and Aβ burden, but it remains unclear how AD-related pathology interacts with participant characteristics to drive white matter disease. Next steps include investigating regional WMH volume, especially posterior regions which we predict will show stronger associations with Aβ burden.
Authors
- Pauline Maillard (ORCID: https://orcid.org/0000-0003-3516-6345)
- Theresa M. Harrison (ORCID: https://orcid.org/0000-0002-2036-3496)
- Trevor Chadwick
- Jacinda Taggett
- Yishu Chao
- William J. Jagust
- Susan M. Landau
- for the Alzheimer's Disease Neuroimaging Initiative for the U.S. POINTER Study Group
- Charles S. DeCarli
Institutions
- Lawrence Berkeley National Laboratory (US)
- University of California, Davis (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_100135
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00