Unraveling the phosphorylation profiles of human‐derived Tau species and their role in seeding competency and Alzheimer's disease progression

This work provides insights into the interplay between Tau post-translational modifications and seeding activity, with potential implications for designing more effective therapeutical strategies that modulate Tau seeding capacity and propagation in AD.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_103417
Primary Topic
Alzheimer's disease research and treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Unraveling the phosphorylation profiles of human‐derived Tau species and their role in seeding competency and Alzheimer's disease progression

M Martins, Noé Quittot, Dhanush Sivasankaran, Bradley T. Hyman
Alzheimer s & Dementia
Alzheimer's disease research and treatments
article

Unraveling the phosphorylation profiles of human‐derived Tau species and their role in seeding competency and Alzheimer's disease progression

M Martins, Noé Quittot, Dhanush Sivasankaran, Bradley T. Hyman
article en

Abstract

This work provides insights into the interplay between Tau post-translational modifications and seeding activity, with potential implications for designing more effective therapeutical strategies that modulate Tau seeding capacity and propagation in AD.

Alzheimer s & DementiaVol. 21(S1)
Harvard University (US), Massachusetts General Hospital (US)
Affordable and clean energy
Openalex Percentile: Top 34%
Alzheimer's disease research and treatments
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