Morphometric Volume‐Function Coupling Across the Clinical Trajectory of Dementia

Morphometric structure-function coupling has widespread increases with worse cognitive status as seen by our significant results across CU, MCI, and dementia participants. These stronger, correlative couplings in MCI and dementia could be due to regional atrophy and disrupted functional connectivity, which causes the relationship between the two variables to be more pronounced as compensatory capacity within the brain is diminished. Future work will incorporate an increased sample size for sufficient power and will evaluate potential cardiovascular influences on the structure-function coupling.