Alzheimer's Disease Frontal Cortex Single Nuclei Transcriptomic Analysis Reveals Allelic and Ancestral Variation in <i>APOE</i> Expression
Our data suggest APOE LA regulates APOE expression in an allele-specific manner. It remains unclear whether this effect is driven by the APOE allele itself or differing regulatory elements in the allele haplotypes. Overall, we observed greater APOE expression in APOE4 carriers than APOE3 carriers across cell types. Given higher APOE4 expression is associated with increased risk, lower APOE3 expression may contribute to lower risk. Altogether, this provides additional insights into the expression regulatory mechanisms in the different APOE alleles, aiding in therapeutic efforts.
Authors
- Patrice Whitehead
- Juan I. Young
- Theresa Schuck
- Derek M. Dykxhoorn (ORCID: https://orcid.org/0000-0002-4998-9943)
- Kara L. Hamilton‐Nelson (ORCID: https://orcid.org/0000-0003-3748-7193)
- Katrina Celis
- Jeffery M. M Vance
- Regina Vontell (ORCID: https://orcid.org/0000-0002-2664-8265)
- David A. Davis (ORCID: https://orcid.org/0000-0002-9323-6180)
- William K. Scott (ORCID: https://orcid.org/0000-0001-9336-6404)
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- Sandra Weintraub
- Luciana Bertholim Nasciben
- Changiz Geula
- Marla Gearing
- Farid Rajabli
- Sofia Moura
- David A. A. Bennett
- Margaret Pericak‐Vance
Institutions
- Northwestern University (US)
- Rush University Medical Center (US)
- University of Miami (US)
- Emory University (US)
- Dr. John T. Macdonald Foundation (US)
- Institute on Aging (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_103564
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00