Elevated brain oxygen extraction fraction (OEF) as a potential marker for vascular cognitive impairment and dementia
We showed that elevated cortical and subcortical OEF was associated with poorer cognition (particularly in executive function) among older adults with vascular risks, suggesting that OEF may be a useful biomarker for VCID.
Authors
- Kaisha Hazel (ORCID: https://orcid.org/0000-0003-0078-3714)
- Yifan Gou (ORCID: https://orcid.org/0009-0009-5836-0299)
- Paul B. Rosenberg (ORCID: https://orcid.org/0000-0003-1106-4299)
- George Pottanat (ORCID: https://orcid.org/0000-0002-3908-7663)
- Chao Xu (ORCID: https://orcid.org/0000-0002-4842-4086)
- R Kalyani
- Ebony Jones
- Hanzhang Lu
- Julia Suconic
- Dengrong Jiang
- Marilyn S. S. Albert
- Sevil Yasar
- Doris Lin
- Wen Shi
- Jie Song
- Kumiko Oishi
- Abhay Moghekar
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_100520
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00