Non‐Toxic Tau Oligomer Polymorph Isolated from Non‐Demented Individuals with Alzheimer's Neuropathology Brains
Our findings suggest that NDAN brains harbor a non-toxic tauO capable of propagating without inducing neuronal death or cognitive decline. These insights open new translational avenues, proposing that converting tauO into less toxic forms could effectively halt AD progression. Moreover, the possibility that tau in NDAN individuals carries mutations or structural modifications that render it less toxic is under investigation, opening new avenues for understanding resilience mechanisms in AD.
Authors
- Shrinath Kadamangudi (ORCID: https://orcid.org/0009-0009-8427-4837)
- Giulio Taglialatela (ORCID: https://orcid.org/0000-0003-4795-447X)
- Michela Marcatti (ORCID: https://orcid.org/0000-0003-1921-4626)
- Anna Fracassi (ORCID: https://orcid.org/0000-0001-9310-8982)
- Jutatip Guptarak
- Pietro Scaduto (ORCID: https://orcid.org/0000-0001-8197-615X)
- Batbayar Tumurbaatar
- Adam Trupp
- Wenru Zhang
- Maria‐Adelaide Micci
Institutions
- The University of Texas Medical Branch at Galveston (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_103856
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00